| 2024-11-11 |
Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda |
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| 2024-11-11 |
What is the real value of omics data? Enhancing research outcomes and securing long-term data excellence |
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| 2024-11-11 |
Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA |
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| 2024-11-11 |
SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency |
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| 2024-11-11 |
Mycobacterium smegmatis NucS-promoted DNA mismatch repair involves limited resection by a 5′-3′ exonuclease and is independent of homologous recombination and NHEJ |
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| 2024-11-11 |
Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1 |
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| 2024-11-11 |
Core enhancers of the 3′RR optimize IgH nuclear position and loop conformation for successful oriented class switch recombination |
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| 2024-11-11 |
Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa |
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| 2024-11-11 |
Localization and discrimination of GG mismatch in duplex DNA by synthetic ligand-enhanced protein nanopore analysis |
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| 2024-11-11 |
Massively parallel binding assay (MPBA) reveals limited transcription factor binding cooperativity, challenging models of specificity |
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| 2024-11-11 |
Correction to ‘Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases’ |
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| 2024-11-11 |
Probing the mechanism of nick searching by LIG1 at the single-molecule level |
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| 2024-11-11 |
Pipolins are bimodular platforms that maintain a reservoir of defense systems exchangeable with various bacterial genetic mobile elements |
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| 2024-11-11 |
Correction to ‘DORQ-seq: high-throughput quantification of femtomol tRNA pools by combination of cDNA hybridization and Deep sequencing’ |
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| 2024-11-11 |
Dual decoding of cell types and gene expression in spatial transcriptomics with PANDA |
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| 2024-11-11 |
Re-appraising the evidence for the source, regulation and function of p53-family isoforms |
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| 2024-11-11 |
Chromosomal integrons are genetically and functionally isolated units of genomes |
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| 2024-11-11 |
Visualization of Type IV-A1 CRISPR-mediated repression of gene expression and plasmid replication |
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| 2024-11-11 |
Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4 |
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| 2024-11-11 |
Revisiting the y-ome of Escherichia coli |
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| 2024-11-11 |
Pathological R-loops in bacteria from engineered expression of endogenous antisense RNAs whose synthesis is ordinarily terminated by Rho |
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| 2024-11-11 |
Self-assembly and condensation of intermolecular poly(UG) RNA quadruplexes |
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| 2024-11-11 |
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators |
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| 2024-11-11 |
Correction to ‘CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses’ |
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| 2024-11-11 |
Establishment of closed 35S ribosomal RNA gene chromatin in stationary Saccharomyces cerevisiae cells |
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| 2024-11-11 |
Altered dNTP pools accelerate tumor formation in mice |
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| 2024-11-11 |
Selective degradation of phage RNAs by the Csm6 ribonuclease provides robust type III CRISPR immunity in Streptococcus thermophilus |
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| 2024-11-11 |
Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork |
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| 2024-11-11 |
Nuclease-induced stepwise photodropping (NISP) to precisely investigate single-stranded DNA degradation behaviors of exonucleases and endonucleases |
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| 2024-11-11 |
Protein–RNA interactions mediated by silvestrol—insight into a unique molecular clamp |
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| 2024-11-11 |
N2-Alkyl-dG lesions elicit R-loop accumulation in the genome |
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| 2024-11-11 |
The TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex |
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| 2024-11-11 |
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil |
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| 2024-11-11 |
Haplotype-resolved de novo assembly revealed unique characteristics of alternative lengthening of telomeres in mouse embryonic stem cells |
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| 2024-11-11 |
The Swi5–Sfr1 complex regulates Dmc1- and Rad51-driven DNA strand exchange proceeding through two distinct three-stranded intermediates by different mechanisms |
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| 2024-11-11 |
The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability |
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| 2024-11-11 |
Human hnRNPA1 reorganizes telomere-bound replication protein A |
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| 2024-11-11 |
Phylogenomic instructed target analysis reveals ELAV complex binding to multiple optimally spaced U-rich motifs |
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| 2024-11-11 |
3,N4-Etheno-5-methylcytosine blocks TET1-3 oxidation but is repaired by ALKBH2, 3 and FTO |
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| 2024-11-11 |
Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code |
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| 2024-11-11 |
Switch-like phosphorylation of WRN integrates end-resection with RAD51 metabolism at collapsed replication forks |
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| 2024-11-11 |
Disparate requirements for RAD54L in replication fork reversal |
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| 2024-11-11 |
p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis |
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| 2024-11-11 |
DciA secures bidirectional replication initiation in Vibrio cholerae |
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| 2024-11-11 |
Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors |
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| 2024-11-11 |
TIRR regulates mRNA export and association with P-bodies in response to DNA damage |
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| 2024-11-11 |
Genome editing outcomes reveal mycobacterial NucS participates in a short-patch repair of DNA mismatches |
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| 2024-10-28 |
Closing in on human methylation—the versatile family of seven-β-strand (METTL) methyltransferases |
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| 2024-10-28 |
Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency |
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| 2024-10-28 |
Combining Nanopore direct RNA sequencing with genetics and mass spectrometry for analysis of T-loop base modifications across 42 yeast tRNA isoacceptors |
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| 2024-10-28 |
Stochastic nature and physiological implications of 5′-NAD RNA cap in bacteria |
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| 2024-10-28 |
DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations |
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| 2024-10-28 |
Testis-specific H2B.W1 disrupts nucleosome integrity by reducing DNA–histone interactions |
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| 2024-10-28 |
A transcription-independent role for HIF-1α in modulating microprocessor assembly |
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| 2024-10-28 |
Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells |
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| 2024-10-28 |
FRAME: flap endonuclease 1-engineered PAM module for precise and sensitive modulation of CRISPR/Cas12a trans-cleavage activity |
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| 2024-10-28 |
Structural and mechanistic insights into a mesophilic prokaryotic Argonaute |
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| 2024-10-28 |
The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state |
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| 2024-10-28 |
Kinetic mechanism and determinants of EF-P recruitment to translating ribosomes |
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| 2024-10-28 |
Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing |
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| 2024-10-28 |
Phage defence loci of Streptococcus thermophilus—tip of the anti-phage iceberg? |
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| 2024-10-28 |
High-throughput single telomere analysis using DNA microarray and fluorescent in situ hybridization |
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| 2024-10-28 |
Polyubiquitinated PCNA triggers SLX4-mediated break-induced replication in alternative lengthening of telomeres (ALT) cancer cells |
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| 2024-10-28 |
G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism |
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| 2024-10-28 |
4CAC: 4-class classifier of metagenome contigs using machine learning and assembly graphs |
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| 2024-10-28 |
Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3 |
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| 2024-10-28 |
A deep learning-based method enables the automatic and accurate assembly of chromosome-level genomes |
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| 2024-10-28 |
Mei5–Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA |
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| 2024-10-28 |
Advancing microRNA target site prediction with transformer and base-pairing patterns |
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| 2024-10-28 |
DNA breathing integration with deep learning foundational model advances genome-wide binding prediction of human transcription factors |
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| 2024-10-28 |
IRescue: uncertainty-aware quantification of transposable elements expression at single cell level |
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| 2024-10-28 |
Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA |
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| 2024-10-28 |
CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver |
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| 2024-10-28 |
DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5 |
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| 2024-10-28 |
MBNL splicing factors regulate the microtranscriptome of skeletal muscles |
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| 2024-10-28 |
A single rare σ70 variant establishes a unique gene expression pattern in the E. coli pathobiont LF82 |
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| 2024-10-28 |
Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization |
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| 2024-10-28 |
LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions |
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| 2024-10-28 |
Elucidating microRNA-34a organisation within human Argonaute-2 by dynamic nuclear polarisation-enhanced magic angle spinning NMR |
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| 2024-10-28 |
DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen |
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| 2024-10-28 |
Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency |
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| 2024-10-28 |
Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs |
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| 2024-10-28 |
The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site |
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| 2024-10-28 |
PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors |
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| 2024-10-28 |
ADAR3 modulates neuronal differentiation and regulates mRNA stability and translation |
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| 2024-10-28 |
Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model |
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| 2024-10-28 |
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops |
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| 2024-10-28 |
Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome |
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| 2024-10-28 |
A plant-specific clade of serine/arginine-rich proteins regulates RNA splicing homeostasis and thermotolerance in tomato |
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| 2024-10-28 |
RNA-directed peptide synthesis across a nicked loop |
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| 2024-10-28 |
A CRISPR-dCas13 RNA-editing tool to study alternative splicing |
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| 2024-10-28 |
RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility |
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| 2024-10-28 |
Sarbecovirus programmed ribosome frameshift RNA element folding studied by NMR spectroscopy and comparative analyses |
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| 2024-10-28 |
KREH2 helicase represses ND7 mRNA editing in procyclic-stage Trypanosoma brucei by opposite modulation of canonical and ‘moonlighting’ gRNA utilization creating a proposed mRNA structure |
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| 2024-10-28 |
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation |
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| 2024-10-14 |
Correction to ‘Expanded MutaT7 toolkit efficiently and simultaneously accesses all possible transition mutations in bacteria’ |
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| 2024-10-14 |
Correction to ‘Advancing quantitative PCR with color cycle multiplex amplification’ |
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| 2024-10-14 |
Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales |
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| 2024-10-14 |
How to scan naked DNA using promiscuous recognition and no clamping: a model for pioneer transcription factors |
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| 2024-10-14 |
Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs |
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